Thermo Fisher Scientific Bcl-10 Polyclonal Antibody
Bcl-10 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 고순도 Protein A 정제, Human/Mouse/Rat 반응성. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Bcl-10, amino acids 81–180 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 acts as an adapter protein linking the upstream TNFR1-TRADD-RIP complex with the downstream NIK-IKK-IKAP complex and serves as a substrate for MALT1. Mutations in the BCL10 gene can lead to Immunodeficiency 37 or mucosa-associated lymphoid type lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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