Thermo Fisher Scientific TAB3 Polyclonal Antibody
TAB3 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ICC/IF에 적합합니다. 인간과 마우스 시료에 반응하며, NF-κB 신호전달 연구에 활용 가능합니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
- 카탈로그번호
- PA5114782
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TAB3 (Accession Q8N5C8), corresponding to amino acid residues Q251–P301 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899418 |
Product Specific Information
Antibody detects endogenous levels of total TAB3.
Target Information
TAB3 functions in the NF-kappaB signal transduction pathway. It, along with the similar protein TAB2, forms a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with pro-inflammatory cytokines such as TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor.
Recent studies have shown that TAB2 and TAB3 constitutively interact with the autophagy mediator Beclin-1. Upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibits autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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