Thermo Fisher Scientific TAB3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total TAB3.

Target Information

TAB3 functions in the NF-kappaB signal transduction pathway. It, along with the similar protein TAB2, forms a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with pro-inflammatory cytokines such as TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor.

Recent studies have shown that TAB2 and TAB3 constitutively interact with the autophagy mediator Beclin-1. Upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibits autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.