Thermo Fisher Scientific TAB2 Polyclonal Antibody
TAB2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. Human 및 Mouse 시료 반응성. Affinity chromatography로 정제된 액상 항체이며, PBS + 50% glycerol buffer에 보관. TAB2 관련 신호전달 및 자가포식 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TAB2 (Accession Q9NYJ8), corresponding to amino acid residues G396–N446 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899417 |
Product Specific Information
Antibody detects endogenous levels of total TAB2.
Target Information
TAB2 is an activator of MAP3K7/TAK1, which is required for IL-1 induced activation of NF-kappaB and MAPK8/JNK. TAB2 forms a kinase complex with TRAF6, MAP3K7, and TAB1, serving as an adaptor linking MAP3K7 and TRAF6. Together with TAB1 and MAP3K7, it participates in TNFSF11/RANKL-induced signal transduction through activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), influencing osteoclast development and function. TAB2 and TAB3 interact with Beclin-1, regulating autophagy by dissociating upon induction and binding TAK1. Overexpression inhibits autophagy, while depletion triggers it, suggesting TAB2/TAB3 act as control points for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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