Thermo Fisher Scientific POMC Recombinant Rabbit Monoclonal Antibody (JE32-88)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

• Positive control: Rat pituitary tissue lysates, rat pituitary tissue, mouse pituitary tissue
• Predicted band size: 29 kDa
• Subcellular Location: Secreted

Target Information

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by prohormone convertases. There are eight potential cleavage sites within the precursor, and depending on tissue type, processing may yield up to ten biologically active peptides with diverse cellular functions.
The protein is mainly synthesized in corticotroph cells of the anterior pituitary, producing adrenocorticotrophin and beta-lipotropin. In other tissues such as hypothalamus and placenta, all cleavage sites may be used, generating peptides involved in pain and energy homeostasis, melanocyte stimulation, and immune modulation.
Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.