Thermo Fisher Scientific TECK Monoclonal Antibody (89818)
Mouse TECK(CCL25) 단백질을 인식하는 Rat IgG2b 단일클론 항체로, Western blot 및 Neutralization 실험에 적합. E.coli 유래 recombinant immunogen 사용, 높은 특이성과 낮은 endotoxin 수준을 보유. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Neutralization (Neu)
- Tested Dilution: 1.5–6.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 89818 |
| Immunogen | E. coli-derived recombinant mouse CCL25/TECK (Gln24–Asn144) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2610309 |
Product Specific Information
- In direct ELISAs, no cross-reactivity with recombinant mouse CCL1–24, recombinant human CCL2–26, or recombinant rat CCL20 is observed.
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).
Target Information
Chemokine C-C thymus expressed chemokine (TECK), also known as chemokine ligand 25 (CCL25), is predominantly expressed in thymic dendritic cells, thymic epithelial cells, and small intestine.
TECK acts as a CCR9 ligand and regulates the trafficking of developing T cells within the thymus. It suppresses proliferation of immature myeloid progenitors stimulated by multiple growth factors and delivers signals through CCR9, which is crucial for thymocyte navigation.
Bone marrow pre-pro-B cells and IL-7/Flt-3 ligand responsive pro-B colony-forming cells migrate to TECK, a response lost in later stages of B cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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