Thermo Fisher Scientific Human LXR alpha Synthetic Peptide
인간 LXRα의 카복시 말단 15개 아미노산 서열에 해당하는 합성 펩타이드. 항체 PA5-20880의 블로킹 펩타이드로 사용 가능. 정제된 액상 형태로 PBS(pH 7.2) 및 0.1% BSA에 보관. 연구용으로만 사용.
- 카탈로그번호
- PEP0994
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human LXR alpha Synthetic Peptide
Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of human LXR-A.
PEP-0994 can be used as a blocking peptide with polyclonal antibody PA5-20880.
Target Information
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from a silent DNA-binding partner to an active ligand-binding subunit, mediating retinoid responses through target genes defined by LXRES.
LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides.
NR1H3 plays an important role in cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interacts with RORA for regulation of genes involved in liver metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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