Thermo Fisher Scientific Tmem119 Monoclonal Antibody (V3RT1GOsz), PE, eBioscience

Thermo Fisher Scientific Tmem119 Monoclonal Antibody (V3RT1GOsz), PE, eBioscience™

Applications and Tested Dilution

• Application: Flow Cytometry
• Tested Dilution: 0.5 µg/test
• Publications: View 3 publications

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 488
• Brilliant UV 805
• Brilliant Violet 421
• PE-Cyanine7
• PerCP-eFluor 710
• Request custom conjugation

Product Specific Information

This V3RT1GOsz monoclonal antibody recognizes mouse Tmem119 and is validated for flow cytometry.

• Applications Reported: Flow cytometric analysis
• Applications Tested: Mouse brain cells after myelin removal
• Recommended Usage: ≤ 0.5 µg/test (in 100 µL final volume)
• Cell Range: 10⁵–10⁸ cells/test
• Laser Compatibility: Blue, Green, Yellow-Green lasers
• Excitation/Emission: 488–561 nm / 578 nm

Target Information

Tmem119 encodes a single-pass type I transmembrane protein that interacts with various microRNAs and transcription factors (SMAD1, SMAD5, RUNX2).
It serves as a specific surface marker for microglia, distinguishing them from infiltrating macrophages. Microglia are phagocytes confined to the brain, involved in debris clearance and neuronal dendrite pruning. They exhibit functional plasticity, balancing neuroprotective and neurotoxic roles.
Reactive microglia co-express Iba1 and have been linked to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and Multiple Sclerosis.
Outside the neural system, Tmem119 is also implicated in osteoblast differentiation and ossification.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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