Thermo Fisher Scientific alpha Internexin Monoclonal Antibody (2E3)

Thermo Fisher Scientific alpha Internexin Monoclonal Antibody (2E3)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

The epitope recognized by the 2E3 clone is located in the C-terminal non-helical extension of the protein and is unusually resistant to aldehyde fixation. This property makes the antibody ideal for studies using formalin-fixed paraffin-embedded histological sections.

Target Information

Alpha-internexin is a Class IV intermediate filament subunit expressed very early in neuronal development. It is related to, but distinct from, the neurofilament triplet proteins (NF-L, NF-M, and NF-H), sharing similar protein sequence motifs and intron organization.
Many classes of mature neurons contain α-internexin along with NF-L, NF-M, and NF-H, while some mature neurons express α-internexin as the only neurofilament subunit.
Antibodies to internexin serve as unique probes to study and classify neuronal types and trace their processes in sections and tissue culture.
Because of its early developmental expression, α-internexin is a convenient diagnostic marker for neuronal progenitor cells and other cells committed to the neuronal lineage.
Although its use in brain tumor studies has not been examined, it may hold potential interest for future research.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.