Thermo Fisher Scientific IL17RB Monoclonal Antibody (752101)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 2.5 µg per million cells

Product Specifications

Product Specific Information

• In direct ELISAs, no cross-reactivity with recombinant human IL-17RB, IL-17R, or recombinant mouse IL-17 was observed.
• Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Target Information

A number of cytokines belonging to the interleukin (IL)-17 family have been identified, including IL-17B, IL-17C, and IL-17E. IL-17 acts as a potent proinflammatory cytokine involved in diseases such as rheumatoid arthritis, multiple sclerosis, and tumor growth promotion.
IL-17B, IL-17C, and IL-17E can induce proinflammatory responses but do not bind to the IL-17 receptor, suggesting the existence of additional IL-17R-related receptors. Receptors for IL-17B and IL-17E have been identified as EV127 (mouse) and IL-17Rh1 (human), respectively.
IL-17E activates the NF-κB pathway and induces IL-8 production. IL-17Rh1 mRNA is highly expressed in kidney and liver, with moderate expression in small intestine, colon, and brain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.