Thermo Fisher Scientific Aconitase 1 Polyclonal Antibody
Thermo Fisher Scientific의 Aconitase 1 Polyclonal Antibody는 인간 및 마우스 시료에 반응하며, Western blot 및 IHC에 적합합니다. N-말단 합성 펩타이드로부터 유래된 항체로, 세포 내 철 항상성 연구에 유용합니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Aconitase 1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:300 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human ACO1 (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2609212 |
Product Specific Information
Peptide sequence:
MSNPFAHLAE PLDPVQPGKK FFNLNKLEDS RYGRLPFSIR VLLEAAIRNC
Sequence homology:
Cow: 100%
Dog: 93%
Guinea Pig: 91%
Horse: 92%
Human: 100%
Mouse: 93%
Pig: 100%
Rabbit: 86%
Rat: 100%
Target Information
Aconitase 1 (ACO1), also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein that binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis.
IREs are stem-loop structures found in the 5′ UTR of ferritin mRNA and in the 3′ UTR of transferrin receptor mRNA. Iron-induced binding to IREs represses ferritin mRNA translation and inhibits degradation of transferrin receptor mRNA, thereby regulating iron metabolism.
ACO1 also exhibits aconitase enzymatic activity and is grouped within the aconitase enzyme family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.