Thermo Fisher Scientific PPP1R10 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Peptide sequence:
SQSSTQPAEK DKKKRKDEGK SRTTLPERPL TEVKAETRAE EAPEKKREKP

Sequence homology:
Cow: 100%; Dog: 100%; Guinea Pig: 79%; Horse: 92%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 92%; Rat: 100%

Target Information

RNA polymerases transcribe nuclear genes for ribosomal RNA, thus representing ribosomal biogenesis.
RNA polymerase I (Pol I) is located in the nucleolus and transcribes class I genes, which code for large ribosomal RNA.
Different subunits of the Pol I transcription machinery are targets of various physiological stimuli, suggesting that multiple signaling pathways are involved in Pol I transcription.
RPA40 and RPA16 are subunits of Pol I that associate with each other at an early stage of RNA polymerase I assembly.
RPA40 is essential for the function and integrity of the complex and is also an essential subunit of RNA polymerase III (Pol III).
RPA40, RPA16, and RPA135 encode the three subunits of RNA polymerase I, respectively.
RPA194 is the largest subunit of RNA Pol I and is not a component of Pol II and Pol III.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.