
Thermo Fisher Scientific AKAP13 Polyclonal Antibody
Rabbit polyclonal antibody targeting human AKAP13 protein. Suitable for Western blot and IHC (paraffin). Unconjugated liquid form, concentration 1 mg/mL. For research use only, not for diagnostic purposes.
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Thermo Fisher Scientific AKAP13 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the internal region of human AKAP13 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555265 |
Target Information
A-kinase anchor proteins (AKAPs) are structurally diverse proteins that bind to the regulatory subunit of protein kinase A (PKA), localizing the holoenzyme within specific cellular compartments.
The AKAP13 gene encodes a member of this family, with multiple transcript variants resulting from alternative splicing. These isoforms contain C-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains.
- The DH domain mediates guanine nucleotide exchange activation for Rho/Rac family GTPases, converting them to their active forms.
- The PH domain contributes to multiple cellular functions.
Together, AKAP13 isoforms act as scaffolding proteins that coordinate Rho signaling pathways, anchor PKA, and enhance ligand-dependent activity of estrogen receptors α and β.
Usage Notes
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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