Thermo Fisher Scientific MREG Polyclonal Antibody
Rabbit polyclonal antibody recognizing human MREG protein. Validated for ICC/IF applications. Antigen affinity purified and supplied as a liquid in PBS with glycerol. Suitable for research use in vesicle transport and pigmentation studies.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human MREG. Recombinant protein control fragment (Product #RP-107643) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664052 |
Product Specific Information
Immunogen sequence:
GLRDWLRTVCC CCGCECLEER ALPEKEPLVS DNNPYSSFGA TLVRDDEKNL WSMPHDVSHT EADDDRTLY
Highest antigen sequence identity to the following orthologs: mouse 86%, rat 86%.
Target Information
MREG probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. It plays a role in hair pigmentation through melanosome-containing vesicle transport between melanocytes and keratinocytes. Functions as a receptor for RILP and DCTN1 complexes, contributing to retrograde melanosome transport. Overexpression leads to accumulation of late endosomes and lysosomes near the microtubule organizing center (MTOC). MREG binds cholesterol and specific phosphatidylinositols, and is required for normal phagosome clearing and lysosomal enzyme activation in retinal pigment epithelium. It also contributes to degradation of lipofuscin component A2E and may regulate disk membrane biogenesis in photoreceptor rod cells. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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