Thermo Fisher Scientific Phospho-Bax (Ser184) Polyclonal Antibody
Bax 단백질의 Ser184 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, IP, peptide-ELISA에 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제되었으며, -20°C에서 보관.
- 카탈로그번호
- PA539778
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | – |
| Immunoprecipitation (IP) | – | View 1 publication |
| peptide-ELISA (pep-ELISA) | 1:10,000 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Bax around the phosphorylation site of Ser184 (T-A-SP-L-T) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco's PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2556329 |
Target Information
BAX is a member of the Bcl-2 family and plays an important role in the regulation of apoptosis. While Bcl-2 is generally anti-apoptotic, BAX promotes apoptosis. Apoptotic regulation involves homo- and heterodimerization among BAX and Bcl-2 isoforms.
The Bax gene encodes multiple isoforms, including Bax alpha (21 kDa) and Bax beta (24 kDa). Both contain BH1, BH2, and BH3 domains, but Bax beta lacks a hydrophobic transmembrane domain.
Bcl-2 also exists in different isoforms; Bcl-2 beta is shorter (22 kDa) than Bcl-2 alpha (26 kDa) and differs in its C-terminus.
Overexpression of BAX promotes cell death through its interactions within the BCL-2 family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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