Thermo Fisher Scientific Caspase 12 Polyclonal Antibody
Caspase-12 단백질 검출용 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며, Human, Mouse, Rat에 반응. ER stress 관련 apoptosis 연구에 활용 가능. 항원 친화 크로마토그래피로 정제된 고순도 항체.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide near the amino terminus of murine Caspase-12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at −20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156032 |
Product Specific Information
A suggested positive control is mouse spleen tissue lysate.
PA5-19962 can be used with blocking peptide PEP-0087.
Target Information
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main ones, involving caspase-8 and caspase-9, respectively. The endoplasmic reticulum (ER) stress is the third apoptotic pathway, in which caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. It is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins involved in Alzheimer’s disease, including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta and is ubiquitously expressed in mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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