Thermo Fisher Scientific Phospho-SLP76 (Ser376) Polyclonal Antibody
SLP76 단백질의 Ser376 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 고순도 액상 형태로 제공되며 인산화 상태 연구에 활용 가능.
- 카탈로그번호
- PA5105200
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human LCP2 (Accession Q13094), corresponding to amino acid residues around phosphorylated Ser376 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816673 |
Product Specific Information
This antibody detects endogenous levels of SLP76 only when phosphorylated at Ser376.
Target Information
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat.
The SLP-76 locus has been localized to human chromosome 5q33 and partially characterized in mice.
Human and murine cDNAs encode 533 amino acid proteins that are 72% identical and composed of three modular domains:
- NH2-terminus: Acidic region with PEST domain and tyrosine residues phosphorylated after TCR ligation
- Central domain: Proline-rich region
- COOH-terminal domain: SH2 domain
SLP-76 interacts with multiple proteins both constitutively and inducibly following receptor ligation, functioning as an adaptor or scaffold protein.
Studies using SLP-76 deficient T cell lines or mice demonstrate its essential role in T cell development, activation, mast cell, and platelet function.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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