Thermo Fisher Scientific RAP1 Polyclonal Antibody
RAP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 적합. 고순도 항원 친화 크로마토그래피 정제. 인간 시료 반응성, 액상 형태, 장기 보관 시 -20°C 권장.
- 카탈로그번호
- PA5110710
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific RAP1 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RAP1. Recombinant protein control fragment (Product #RP-89492). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856121 |
Product Specific Information
Immunogen sequence:
REFEEVVVDE SPPDFEIHIT MCDDDPPTPE EDSETQPDEE EEEEEEKVSQ PEVGAAIKII RQLMEKFNLD LSTVTQAFLK NSGELEATSA FLASGQRADG YPIWSRQDDI DLQKDDEDTR EALVKKFGAQ NVAR
Target Information
Human Rap1 was the first identified ortholog of the yeast telomeric protein scRap1, which shares three conserved sequence motifs in common. HRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1. The hRap1 cDNA codes for a protein of 399 amino acids with an approximate molecular weight of 47 kDa. The hRap1 protein does not interact with TRF1.
TRF2 is a ubiquitously expressed protein implicated in the control of telomere length. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. Mutant forms of TRF2 have been shown to play a role in preventing senescence in primary human cells, and inhibition of TRF2 can result in apoptosis in certain mammalian cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.