Thermo Fisher Scientific NPTX2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 90-240 of human NPTX2 (NP_0025141) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NPTX2,uniProtId:P47972-1,ncbiNodeId:9606,antigenRange:90-240,antigenLength:431,antigenImageFileName:PA5-88307_NPTX2_P47972-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88307_NPTX2_P47972-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.43 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804818

Product Specific Information

Immunogen sequence: KLARCEGLAG GKARGAGATG KDTMGDLPRD PGHVVEQLSR SLQTLKDRLE SLEHQLRANV SNAGLPGDFR EVLQQRLGEL ERQLLRKVAE LEDEKSLLHN ETSAHRQKTE STLNALLQRV TELERGNSAF KSPDAFKVSL PLRTNYLYGK I; Positive Samples: SH-SY5Y, BxPC-3, LO2

Target Information

Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson`s disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.