Thermo Fisher Scientific PCDHGC5 Monoclonal Antibody (OTI2D6)
PCDHGC5 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 파라핀 포매 조직 면역조직화학(IHC-P)에 적합합니다. 인간 시료 반응성이 있으며, 액상 형태로 제공됩니다. 친화 크로마토그래피로 정제되었으며, 안정적인 PBS 버퍼에 보존됩니다.
- 카탈로그번호
- MA526921
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 35–258 of PCDHGC5 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724957 |
Target Information
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression.
The gamma gene cluster includes 22 genes divided into 3 subfamilies:
- Subfamily A contains 12 genes
- Subfamily B contains 7 genes and 2 pseudogenes
- Subfamily C contains 3 genes
The tandem array of 22 large, variable region exons are followed by a constant region containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region.
These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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