Thermo Fisher Scientific PEN2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

3-7 µg/mL

-

Product Specifications

Species Reactivity

Bovine, Dog, Horse, Human, Marsupial, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A portion of amino acid 1 to 50 of human Presenilin enhancer protein 2 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PEN2,uniProtId:Q9NZ42-1,ncbiNodeId:9606,antigenRange:1-50,antigenLength:101,antigenImageFileName:PA5-23447_PEN2_Q9NZ42-1_Rabbit.svg,antigenImageFileNamePDP:PA5-23447_PEN2_Q9NZ42-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2540947

Target Information

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer`s disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.