Thermo Fisher Scientific Human PDGF-BB Recombinant Protein, PeproTech
인간 유래 PDGF-BB 재조합 단백질로, 세포 증식 및 기능 분석에 사용됩니다. E. coli 발현 시스템에서 생산되며, ≥98% 순도와 낮은 엔도톡신 수준(<1 EU/µg)을 보장합니다. Western blot, ELISA, 기능적 분석 등 다양한 연구 응용에 적합합니다.
- 카탈로그번호
- 100-14B-xxx (7개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
7개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human PDGF-BB Recombinant Protein, PeproTech
Applications
- Western Blot (WB): Assay-dependent
- ELISA: Assay-dependent
- Functional Assay: Assay-dependent
- In vitro Assay: Assay-dependent
- Miscellaneous PubMed: Refer to publications for details
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Bovine, Dog, Guinea pig, Human, Mouse, Non-human primate, Pig, Rat, Sheep |
| Expression System | E. coli |
| Amino Acid Sequence | SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT |
| Molecular Weight | 24.3 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Dose-dependent stimulation of Balb/c 3T3 cell proliferation (ED50: 1.0–3.0 ng/ml) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two beta chains (218 total amino acids).
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
The protein encoded by this gene belongs to the platelet-derived growth factor (PDGF) family. Members of this family are mitogenic factors for cells of mesenchymal origin and share a characteristic motif of eight cysteines.
PDGF-BB can exist as a homodimer or as a heterodimer (PDGF-AB) with the PDGF alpha polypeptide, linked by disulfide bonds.
Mutations in this gene are associated with meningioma, and translocations involving chromosomes 22 and 7 (COL1A1 locus) are linked to dermatofibrosarcoma protuberans, resulting in unregulated growth factor expression.
Two alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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