Thermo Fisher Scientific Pan-cadherin Monoclonal Antibody (GT2610)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

GT2610

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of Human cadherin. The exact sequence is proprietary. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Pan-cadherin,uniProtId:P19022-1,ncbiNodeId:9606,antigenRange:906,antigenLength:906,antigenImageFileName:MA5-27736_Pan-cadherin_P19022-1_House_mouse.svg,antigenImageFileNamePDP:MA5-27736_Pan-cadherin_P19022-1_House_mouse_PDP.jpeg,sortOrder:1},{targetFamily:Pan-cadherin,uniProtId:P12830-1,ncbiNodeId:9606,antigenRange:882,antigenLength:882,antigenImageFileName:MA5-27736_Pan-cadherin_P12830-1_House_mouse.svg,antigenImageFileNamePDP:MA5-27736_Pan-cadherin_P12830-1_House_mouse_PDP.jpeg,sortOrder:2},{targetFamily:Pan-cadherin,uniProtId:P22223-1,ncbiNodeId:9606,antigenRange:829,antigenLength:829,antigenImageFileName:MA5-27736_Pan-cadherin_P22223-1_House_mouse.svg,antigenImageFileNamePDP:MA5-27736_Pan-cadherin_P22223-1_House_mouse_PDP.jpeg,sortOrder:3},{targetFamily:Pan-cadherin,uniProtId:P55283-1,ncbiNodeId:9606,antigenRange:916,antigenLength:916,antigenImageFileName:MA5-27736_Pan-cadherin_P55283-1_House_mouse.svg,antigenImageFileNamePDP:MA5-27736_Pan-cadherin_P55283-1_House_mouse_PDP.jpeg,sortOrder:4}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.75 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735301

Product Specific Information

Positive Control: IMR32, SK-N-AS, MCF-7

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin`s function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.