Thermo Fisher Scientific PDXK Polyclonal Antibody
Rabbit polyclonal antibody targeting human PDXK protein. Validated for WB, IHC-P, and IP applications. Unconjugated liquid form with 0.71 mg/mL concentration. For research use only; not for diagnostic or resale purposes. Provides reliable detec...
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Thermo Fisher Scientific PDXK Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunoprecipitation (IP) | 1–5 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human PDXK fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.71 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902755 |
Target Information
Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis indicates that a major 1.5-kb PDXK transcript is expressed in all tested tissues. PDXK expression exhibits circadian oscillations. In mouse liver and brain, expression is regulated by the three PAR bZIP transcription factors (Dbp, Hlf, and Tef), which also show circadian oscillations. Mice lacking all three transcription factors display reduced levels of brain PLP, serotonin, and dopamine, and are highly susceptible to spontaneous and audiogenic epilepsies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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