Thermo Fisher Scientific PDGF-D Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunoprecipitation (IP)

• Tested Dilution: 1–5 µL/mg of lysate

Product Specifications

Target Information

The platelet-derived growth factor (PDGF) family consists of four members: PDGF-A, PDGF-B, PDGF-C, and PDGF-D (also known as spinal cord-derived growth factor-B or iris-expressed growth factor). PDGF members form disulfide-bonded dimeric isoforms, which are important for growth, survival, and function in several types of connective tissue cells. Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-α and PDGFR-β, and PDGF-mediated signaling is critical for development of many organ systems.

PDGF-D has a two-domain structure similar to PDGF-C and is secreted as a disulfide-linked homodimer, PDGF-DD. PDGF-D induces cellular transformation and promotes tumor growth by accelerating the proliferation rate of tumor cells and stimulating tumor neovascularization. PDGF-D may play a role in the development of brain tumors. The potential oncogenic activity of PDGF-DD may be important for the development and/or progression of prostate cancer. PDGF-D is expressed in fibroblastic adventitial cells, cultured endothelial cells, and in a variety of tumor cell lines including those derived from ovarian, renal, and lung cancers, as well as astrocytomas and medulloblastomas. PDGF-D is expressed in the human kidney.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.