Thermo Fisher Scientific CD20/MS4A1 (B-Cell Marker) Monoclonal Antibody (SPM618)
인간 CD20/MS4A1 표적 단클론 항체로, B 세포 마커 검출에 적합합니다. IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. 고순도 Protein A/G 정제, 액상 형태로 안정적 보관. 연구용으로만 사용.
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Thermo Fisher Scientific CD20/MS4A1 (B-Cell Marker) Monoclonal Antibody (SPM618)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM618 |
| Immunogen | Recombinant human MS4A1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD20 is a non-glycosylated surface phosphoprotein with a molecular weight of 33–37 kDa depending on phosphorylation level. It is expressed on mature and most malignant B cells, a subpopulation of T lymphocytes, and follicular dendritic cells. CD20 expression is synchronous with surface IgM and regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation.
CD20 associates with lipid rafts, and its intensity varies depending on extracellular triggering, conformational changes, or BCR aggregation. Upon receptor ligation, CD20 and BCR colocalize and then dissociate before BCR endocytosis, while CD20 remains at the cell surface.
CD20 is a valuable target for antibody-mediated B-cell depletion therapy, as it is highly expressed on B-cell malignancies and remains on the membrane after treatment. Diseases associated with CD20 dysfunction include MS4A1-related common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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