Thermo Fisher Scientific beta Amyloid Polyclonal Antibody
Human 및 Mouse에서 반응하는 beta Amyloid 폴리클로날 항체로 Western blot 및 IHC에 사용 가능. 모든 mAPP isoform과 Amyloid beta peptide 길이에 반응. 고순도(Ammonium sulfate precipitation) 및 안정적 액상 형태로 제공. Alzheimer’s disease 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 0.03–0.1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence DAEFGHDSGFEVRHQK-C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2933456 |
Product Specific Information
This antibody is expected to recognize all reported isoforms of mAPP (NP_001185752.1; NP_031497.2; NP_001185753.1; NP_001185754.1; NP_001185755.1) and all lengths of the putative mouse Amyloid beta peptide.
Tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process:
- Cleavage of the extracellular, amino-terminal domain of beta APP by beta-secretase (BACE).
- Further processing by gamma-secretase, producing the amyloid beta peptide.
Gamma-secretase is a multi-subunit complex containing presenilin-1 and -2 as central components. Nicastrin, a transmembrane glycoprotein, associates with presenilins and modulates amyloid beta peptide production.
Abeta is an extracellular filamentous protein found in amyloid cores, neuritic plaques, and neurofibrillary tangles.
Beta amyloid deposits are detected in:
- Alzheimer’s disease (senile dementia)
- Lewy body dementia
- Down’s syndrome
- Amyloidosis (Dutch type)
- Cerebroarterial amyloidosis (cerebral amyloid angiopathy)
- Guam Parkinson-Dementia complex
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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