ELK Biotechnology Histone H2A.Z (Acetyl Lys12) rabbit pAb
Histone H2A.Z (Acetyl Lys12) 특이적 rabbit polyclonal antibody로, WB 및 ELISA에 적합합니다. 인간, 마우스, 랫에서 반응하며, 핵 내 히스톤 변형 연구에 활용됩니다. 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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Histone H2A.Z (Acetyl Lys12) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Histone H2A.Z (Acetyl Lys12) rabbit pAb |
| Alternative Names | Histone H2A.Z (H2A/z) |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:1000–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human Histone H2A.Z (Acetyl Lys12) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 15 kD |
| Gene ID (Human) | 3015 |
| Human Swiss-Prot No. | P0C0S5 |
| Cellular Localization | Nucleus, Chromosome |
| Species Reactivity | Human, Mouse, Rat |
Background
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to cellular machineries that require DNA as a template. Histones play a central role in transcription regulation, DNA repair, replication, and chromosomal stability.
DNA accessibility is regulated via post-translational modifications of histones (histone code) and nucleosome remodeling. H2A.Z may be involved in constitutive heterochromatin formation and chromosome segregation during cell division.
Post-translational Modifications (PTM):
- Acetylated on Lys-5, Lys-8, and Lys-12 during interphase (acetylation disappears at mitosis).
- Monoubiquitination of Lys-122 acts as a tag for epigenetic transcriptional repression.
- Not phosphorylated.
Structure and Similarity:
- Belongs to the histone H2A family.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3, and H4, assembled as one H3-H4 heterotetramer and two H2A-H2B heterodimers.
- H2A.Z forms a heterodimer with H2B and interacts with INCENP.
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