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ELK Biotechnology GATA-1 (Acetyl Lys312) rabbit pAb
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GATA-1 (Acetyl Lys312) rabbit pAb는 적혈구 발달 관련 전사인자 GATA-1을 인식하는 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며 고순도 IgG 형태로 제공됩니다. 핵 내 단백질 검출에 유용합니다.
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- pk
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ELK Biotechnology ES20070-100UL GATA-1 (Acetyl Lys312) rabbit pAb, 100UL pk판매 단위 pk ·
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ELK Biotechnology ES20070-50UL GATA-1 (Acetyl Lys312) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology GATA-1 (Acetyl Lys312) rabbit pAb
제품명
GATA-1 (Acetyl Lys312) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Erythroid transcription factor (Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein) |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:1000–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human GATA-1 (Acetyl Lys312) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 45 kD |
| GeneID (Human) | 2623 |
| Human Swiss-Prot No | P15976 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse; Rat |
배경 (Background)
Defects in GATA1 are associated with:
- X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [MIM:300367]: characterized by abnormal erythrocyte morphology and platelet deficiency.
- X-linked thrombocytopenia with beta-thalassemia (XLTT) [MIM:314050]: features thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis.
Functional Domains:
- Contains two GATA-type zinc fingers that cooperate for specific and stable DNA binding.
- The first finger contributes to specificity and stability; the second is essential for DNA binding.
Function:
- Acts as a transcriptional activator and general switch factor for erythroid development.
- Binds to DNA consensus sequence [AT]GATA[AG] in regulatory regions of globin and other erythroid genes.
Post-translational Modifications (PTM):
- Highly phosphorylated on serine residues.
- Phosphorylation on Ser-310 increases during erythroid differentiation.
- Phosphorylation on Ser-142 promotes sumoylation on Lys-137.
- Sumoylation by SUMO1 does not affect transcriptional activity.
Protein Interactions:
- Interacts with ZFPM1, GFI1B, and PIAS4 (enhances sumoylation and represses transactivation activity).
- Tissue specificity: Erythrocytes.
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