ELK Biotechnology BACE (Acetyl Lys316) rabbit pAb

제품명

BACE (Acetyl Lys316) rabbit pAb

공급업체

ELK Biotechnology

제품 개요

이 항체는 인간 BACE1 단백질의 Acetyl Lys316 부위를 인식하는 rabbit polyclonal antibody로, 베타-아밀로이드 생합성 연구에 유용합니다. Western blot(WB)과 ELISA 등 다양한 면역학적 분석에 적합합니다.

스펙 정보

세포 내 위치

Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network, Endoplasmic reticulum, Endosome, Cell surface, Cytoplasmic vesicle membrane, Membrane raft, Lysosome, Late endosome, Early endosome, Recycling endosome, Cell projection (axon, dendrite).
Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes, and on the cell surface.
Colocalization with APP in early endosomes is due to the addition of bisecting N-acetylglucosamine, which blocks targeting to late endosomes and lysosomes. Retrogradly transported from endosomes.

Background

beta-secretase 1 (BACE1)
This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease.
This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer’s disease patients.
[provided by RefSeq, Nov 2015]