ELK Biotechnology p53 (Tri Methyl Lys370) rabbit pAb

ELK Biotechnology p53 (Tri Methyl Lys370) rabbit pAb

제품 개요

Human p53 단백질의 Tri Methyl Lys370에 특이적인 rabbit polyclonal antibody입니다. 세포 내 p53의 메틸화 상태 연구 및 종양 억제 관련 연구에 활용됩니다.

제품 정보

세포 내 위치 (Cellular Localization)

Cytoplasm, nucleus, PML body, endoplasmic reticulum, mitochondrion matrix, cytoskeleton (microtubule organizing center, centrosome).
Translocates to mitochondria upon oxidative stress or mitomycin C treatment.
Isoform별로 핵과 세포질에서 다양한 분포를 보임.

단백질 기능 및 특성 (Background)

• Cofactor: Binds 1 zinc ion per subunit.
• Function: Tumor suppressor; induces growth arrest or apoptosis depending on cell type and physiological conditions. Regulates cell cycle via inhibition of cyclin-dependent kinases.
• Disease Associations:
  • Li-Fraumeni syndrome (LFS)
  • Choroid plexus papilloma
  • Lung cancer
  • Hereditary adrenocortical carcinoma
  • Barrett esophagus
  • Esophageal, head and neck, and oral squamous cell carcinomas
  • Nasopharyngeal carcinoma
  • TP53 mutations found in ~60% of cancers

구조 및 상호작용 (Subunit and Similarity)

• Binds DNA as a homotetramer
• Interacts with AXIN1, HIPK1, HIPK2, TP73, WWOX, USP7, SYVN1, HSP90AB1, CHD8, BANP, CDKN2AIP, E4F1, YWHAZ, and MAML1
• Belongs to the p53 family

Post-translational Modifications (PTMs)

• Acetylation: Lys-382 by CREBBP enhances transcriptional activity; deacetylation by SIRT1 impairs apoptosis induction
• Methylation: Lys-370 and Lys-372 methylation affect DNA-binding and transcriptional regulation
• Phosphorylation: Multiple Ser/Thr sites modulate transcriptional activation and degradation pathways
• Sumoylation & Ubiquitination: Regulate protein stability and degradation

참고 정보 (Online Information)

• P53 entry
• Somatic and germline TP53 mutations in human cancers
• The Singapore human mutation and polymorphism database

제품 이미지

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