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ELK Biotechnology FA10 (light chain, Cleaved-Arg179) rabbit pAb
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FA10(light chain, Cleaved-Arg179)에 특이적인 rabbit polyclonal antibody로, WB 및 ELISA에 적합합니다. 인간, 생쥐, 랫드 시료에서 반응하며, Factor X 관련 연구에 활용됩니다. -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
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ELK Biotechnology ES20000-100UL FA10 (light chain, Cleaved-Arg179) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES20000-50UL FA10 (light chain, Cleaved-Arg179) rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology FA10 (light chain, Cleaved-Arg179) rabbit pAb
제품명
FA10 (light chain, Cleaved-Arg179) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Coagulation factor X (EC 3.4.21.6; Stuart factor; Stuart-Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain] |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:1000–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human FA10 (light chain, Cleaved-Arg179) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 15, 53 kDa |
| GeneID (Human) | 2159 |
| Human Swiss-Prot No | P00742 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Rat; Mouse |
Background
- Catalytic activity: Selective cleavage of Arg–Thr and Arg–Ile bonds in prothrombin to form thrombin.
- Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin with factor Va, calcium, and phospholipid during blood clotting.
- Post-translational modifications (PTM):
- N- and O-glycosylated
- Activation peptide cleaved by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway)
- Iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains
- Vitamin K-dependent carboxylation of glutamate residues enables calcium binding
- Similarity:
- Belongs to the peptidase S1 family
- Contains 1 Gla (gamma-carboxy-glutamate) domain
- Contains 1 peptidase S1 domain
- Contains 2 EGF-like domains
- Subunit: Two chains formed from a single-chain precursor by excision of two Arg residues, held by disulfide bonds
- Tissue specificity: Plasma; synthesized in the liver
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