Thermo Fisher Scientific CCR4 Polyclonal Antibody
CCR4 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 Immunocytochemistry에 사용 가능하며, Protein G로 정제된 1 mg/mL 액상 형태입니다. 연구용으로 Th2 세포 관련 연구에 적합합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 337–351 of human CCR4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2074398 |
Product Specific Information
Suggested positive control: Daudi.
Target Information
CCR4 is a chemokine receptor preferentially expressed on type 2 helper T (Th2-type) cells. Unlike other chemokine receptors, CCR4 and CCR8 expression on Th2 cells transiently increases following TCR and CD28 engagement. Activated Th1 cells also up-regulate CCR4 expression and responsiveness to thymus- and activation-regulated chemokine.
Chemokines are small (8–14 kDa), mostly basic, structurally related molecules that regulate leukocyte trafficking via 7-transmembrane, G protein-coupled receptors. They play key roles in immune system development, homeostasis, and function, and also affect CNS and endothelial cells involved in angiogenesis or angiostasis.
Chemokines are divided into two major subfamilies:
- CXC chemokines: Two conserved cysteines separated by one amino acid
- CC chemokines: Two conserved cysteines adjacent to each other
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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