Thermo Fisher Scientific Cardiac Troponin I Monoclonal Antibody (M18)
Cardiac Troponin I 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, IP, AP 등 다양한 면역분석에 사용 가능. 인간 시료에 반응하며, 단백질 A로 정제된 액상 형태. 심근 손상 연구 및 트로포닌 복합체 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| Affinity Purification (AP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M18 |
| Immunogen | Free, human cardiac troponin and/or native troponin complex |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 7.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_561837 |
Product Specific Information
MA1-20120 detects cardiac troponin I in human samples.
Target Information
Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT).
The TnT subunit binds to tropomyosin to form a troponin-tropomyosin complex anchored by TnI binding to actin within muscle thin filaments.
When calcium binds to specific sites on TnC, structural changes release the inhibitory region of TnI from actin, enabling myosin attachment and muscle contraction.
Measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage and can differentiate between angina and myocardial infarction.
Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro.
Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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