Thermo Fisher Scientific ABCA9 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ABCA9 protein for WB and IHC applications. Recognizes aa 350-400 region of ABCA9. Lyophilized form, unconjugated, for research use only. Ideal for studies on monocyte differentiation and lipid homeostasis.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 350–400 of human ABCA9 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: ABCA9.
Target Information
ABCA9 (ATP-binding cassette, sub-family A (ABC1), member 9) is a 1,624 amino acid protein belonging to the ABC transporter superfamily and the ABCA family. The ABC1 subfamily is the only major ABC subfamily exclusive to multicellular eukaryotes.
Ubiquitously expressed with high expression in heart, brain, and fetal tissues, ABCA9 is a multi-pass membrane protein containing two ABC transporter domains and exists as five alternatively spliced isoforms.
ABCA9 exhibits membrane subcellular localization and may play a role in monocyte differentiation and lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages and down-regulated by cholesterol loading of macrophages.
Spanning 85 kb, ABCA9 contains 39 exons, with a non-coding first exon.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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