Thermo Fisher Scientific RET Polyclonal Antibody
RET 단백질을 표적으로 하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 비결합(Unconjugated) 액상 형태로 제공되며, 1 mg/mL 농도. 인간 RET Tyr905 부위에서 유래한 합성 펩타이드 면역원 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic non-phosphopeptide derived from human Ret around the phosphorylation site of Tyr905 (D-S-YP-V-K) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555109 |
Target Information
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development and can undergo oncogenic activation by cytogenetic rearrangement. RET transduces signals for cell growth and differentiation.
Mutations in the RET gene are associated with multiple endocrine neoplasia type IIA and IIB, Hirschsprung disease, and medullary thyroid carcinoma.
Two transcript variants encoding different isoforms have been found for the RET gene. Additional transcript variants have been described but their biological validity has not been confirmed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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