Thermo Fisher Scientific JMY Polyclonal Antibody
Rabbit polyclonal antibody recognizing human JMY protein. Suitable for Western blot applications. Unconjugated liquid form with 1 mg/mL concentration. Stored at -20°C and shipped on wet ice. For research use only, not for diagnostic purposes.
- 판매단위
- pk
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Thermo Fisher Scientific JMY Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human JMY |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555113 |
Target Information
JMY acts both as a nuclear p53/TP53 cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In the nucleus, it increases p53/TP53 response via interaction with p300/EP300, enhancing p53/TP53-dependent transcription and apoptosis. In the cytoplasm, JMY serves as a nucleation-promoting factor for both branched and unbranched actin filaments, activating the Arp2/3 complex to induce branched networks and catalyzing actin polymerization independently of Arp2/3 for unbranched filaments. It contributes to cell motility by controlling actin dynamics and may promote rapid formation of branched actin networks by nucleating mother filaments and activating Arp2/3 to branch off them. The dual roles of JMY as a p53/TP53 cofactor and actin activator are regulated by its subcellular localization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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