Thermo Fisher Scientific beta Glucan Receptor Polyclonal Antibody
베타 글루칸 수용체를 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, Flow cytometry, ELISA 등에 사용 가능. 인간, 생쥐, 랫트 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Flow Cytometry (Flow) | 1:20–100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Beta-glucan receptor (amino acids 41–140) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CLEC7A (also known as Dectin-1) is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells.
It is a small type II membrane glycoprotein receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain containing an immunoreceptor tyrosine-based activation motif (ITAM).
CLEC7A functions as a pattern-recognition receptor that recognizes β-1,3-linked and β-1,6-linked glucans from fungi and plants, playing an essential role in innate immune responses.
Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, leading to reactive oxygen species formation and oxidative burst.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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