Thermo Fisher Scientific FNTA Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total FNTA.

Target Information

FNTA (Farnesyltransferase, CAAX box; alphaCAAX farnesyltransferase alpha subunit, FPTA, FTase-alpha, GGTase-I-alpha, Protein farnesyl transferase/geranyl geranyl transferase type I alpha subunit (PGGT1A), Ras proteins prenyl transferase alpha, Type I protein geranyl-geranyl transferase alpha subunit) is located at locus 8p11 (human).

Prenylation is a common intracellular posttranslational protein modification catalyzed by prenyltransferases. The CAAX farnesyl transferase (EC 2.5.1.21) is an alpha-beta heterodimeric enzyme that catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from the C-terminus of proteins ending in the CAAX box. FNTA, the alpha subunit of farnesyl transferase, is shared by geranyl-geranyl protein transferases. It may also regulate intracellular signaling pathways involving p21ras and interact with TGF-beta and activin-type I receptors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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