Thermo Fisher Scientific Phospho-c-Abl (Ser569) Polyclonal Antibody
Human c-Abl 단백질의 Ser569 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human c-Abl isoform a around the phosphorylation site of Ser569 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response. The activity of c-Abl protein is negatively regulated by its SH3 domain; deletion of this domain converts c-Abl into an oncogene. Its DNA-binding activity is regulated by CDC2-mediated phosphorylation, suggesting a role in the cell cycle.
In chronic myelogenous leukemia (CML) and some acute lymphoblastic leukemias (ALL), the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation, forming the Philadelphia chromosome through fusion of c-Abl (chromosome 9) with the Bcr gene (chromosome 22). The c-Abl oncogene was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV) and may regulate DNA repair by activating proapoptotic pathways when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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