Thermo Fisher Scientific CD16b VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (C21)
CD16b 단백질을 표적으로 하는 알파카 유래 재조합 단일클론 항체입니다. ELISA 및 기능적 분석에 사용 가능하며, CHO 세포에서 발현되었습니다. Human CD16b에 특이적으로 반응하며, Metal-chelate chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
ELISA (ELISA)
- Assay-dependent
Functional Assay
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Alpaca / VHH |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | C21 |
| Immunogen | Recombinant Human CD16b/FCGR3B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Compatible with Direct ELISA
Target Information
CD16 (FCGR3A) is a 50–65 kDa cell surface molecule that exists in two forms: a transmembranous form expressed by NK cells and some T cells, and a phosphatidylinositol-linked form expressed by granulocytes.
CD16 is a low-affinity receptor for IgG (FcR III) and is an important receptor mediating antibody-dependent cellular cytotoxicity (ADCC) by NK cells.
Human CD16 is expressed in two forms—FCGR3A and FCGR3B. FCGR3A is associated with the FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FCGR3A is associated with the FcepsilonRI-beta subunit.
Besides IgG, FCGR3A can also be triggered by oligomeric IgE. FCGR3B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a pro-adhesive phenotype.
Diseases associated with CD16 dysfunction include immunodeficiency 20 and systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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