Thermo Fisher Scientific CD16b VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (C21)

Applications

ELISA (ELISA)

• Assay-dependent

Functional Assay

• Assay-dependent

Product Specifications

Product Specific Information

• Compatible with Direct ELISA

Target Information

CD16 (FCGR3A) is a 50–65 kDa cell surface molecule that exists in two forms: a transmembranous form expressed by NK cells and some T cells, and a phosphatidylinositol-linked form expressed by granulocytes.
CD16 is a low-affinity receptor for IgG (FcR III) and is an important receptor mediating antibody-dependent cellular cytotoxicity (ADCC) by NK cells.
Human CD16 is expressed in two forms—FCGR3A and FCGR3B. FCGR3A is associated with the FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FCGR3A is associated with the FcepsilonRI-beta subunit.
Besides IgG, FCGR3A can also be triggered by oligomeric IgE. FCGR3B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a pro-adhesive phenotype.
Diseases associated with CD16 dysfunction include immunodeficiency 20 and systemic lupus erythematosus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.