Thermo Fisher Scientific TNFRSF18 Monoclonal Antibody (OTI1A3), TrueMAB
TNFRSF18 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, Western blot 및 Flow cytometry에 사용 가능. Human 시료 반응성. 고순도 친화 크로마토그래피 정제. 안정적 액상 형태로 -20°C에서 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A3 |
| Immunogen | Human recombinant protein fragment (aa 26–162 of TNFRSF18) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is a human protein encoded by the TNFRSF18 gene located at 1p36.33.
This receptor belongs to the TNF-receptor superfamily and its expression increases upon T-cell activation. It plays a key role in maintaining immunological self-tolerance mediated by CD25(+)CD4(+) regulatory T cells.
Mouse knockout studies indicate that TNFRSF18 is involved in regulating CD3-driven T-cell activation and programmed cell death.
Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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