Thermo Fisher Scientific CRMP1 Polyclonal Antibody
Human CRMP1 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 시약이며, 신경세포 분화 및 축삭 성장 연구에 적합. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:2,500–1:5,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CRMP1. Recombinant protein control fragment (Product #RP-96604). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856476 |
Product Specific Information
Immunogen sequence: QGKIVFEDGN INVNKGMGRF IPRKAFPEHL YQRVK
Target Information
Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain, where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and olfactory system suggests involvement in adult brain plasticity.
CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain; later studies have shown its role in neurotrophin (NT)3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, indicating involvement in early neuronal differentiation and later survival or death processes of newly generated neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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