Thermo Fisher Scientific Human ATP11A Synthetic Peptide
Human ATP11A 단백질의 N-말단 19개 아미노산에 해당하는 합성 펩타이드. ATP11A 항체의 블로킹 실험에 사용 가능. 정제된 액상 형태로 제공되며 PBS 버퍼에 0.1% BSA 포함. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 19 amino acids near the amino terminus of human ATP11A.
PEP-1109 can be used as a blocking peptide with polyclonal antibody PA5-20995.
Target Information
ATP11A is a widely expressed integral membrane ATPase. It is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes.
While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs).
Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug.
Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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