Thermo Fisher Scientific C-Myc Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression. Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with cell proliferation and regulation.

c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression of c-Myc can induce apoptosis in multiple cell types. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either the N- or C-terminus of target proteins.

Amplification of the c-Myc gene has been identified in several human tumors, including lung, breast, and colon carcinomas. Translocation of the c-myc locus (chromosome 8) to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell proliferative disorders. Aberrant expression of c-Myc occurs in tumors of diverse origins, such as colorectal, gastric, hepatic, mammary, ovarian, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.