Thermo Fisher Scientific OLIG2 (Marker of Glial Brain Tumors) Recombinant Rabbit Monoclonal Antibody (OLIG2/7366R)
OLIG2 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, 교세포성 뇌종양 연구에 적합. IHC(P) 및 IHC(PFA) 실험에 사용 가능. 인간 시료 반응성, HEK293 발현 시스템 기반. 단백질 A/G 정제 및 PBS 완충액에 보관. 연구용 전용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | OLIG2/7366R |
| Immunogen | Recombinant fragment (around aa200–300) of human OLIG2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
This gene encodes a basic helix-loop-helix transcription factor expressed in oligodendroglial tumors of the brain. The protein regulates ventral neuroectodermal progenitor cell fate and is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. The gene is located on chromosome 21, a region implicated in learning deficits related to Down syndrome.
Tissue specificity:
Expressed in the brain, particularly in oligodendrocytes. Strong expression in oligodendrogliomas, weak to moderate in astrocytomas, and variable in glioblastomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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