Thermo Fisher Scientific OLIG2 (Marker of Glial Brain Tumors) Monoclonal Antibody (OLIG2/2400)
OLIG2 단백질을 인식하는 마우스 단클론 항체로, 신경교종 및 뇌종양 연구에 적합. IHC(P), IHC(PFA), Peptide Array 등 다양한 응용에 사용 가능. 단백질 A/G로 정제된 액상 형태이며, 보존제 없이 PBS(pH 7.4)에 용해. -20°C 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OLIG2/2400 |
| Immunogen | Recombinant fragment of human OLIG2 protein (around aa 1–141) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
This gene encodes a basic helix-loop-helix transcription factor expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 suggested to play a role in learning deficits associated with Down syndrome.
Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, weak to moderate in astrocytomas, and variably in glioblastomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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