Thermo Fisher Scientific IL-22 Monoclonal Antibody (2A10B9)
인간 IL-22를 인식하는 Mouse IgG2a 단클론 항체로 다양한 면역분석(WB, IHC, ICC, Flow, ELISA)에 사용 가능. 고순도 Protein G 정제 및 PBS 보존액에 0.05% sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- MA548745
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-22 Monoclonal Antibody (2A10B9)
Thermo Fisher Scientific IL-22 Monoclonal Antibody (2A10B9)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2A10B9 |
| Immunogen | Purified recombinant fragment of human IL22 (AA: 34–179) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090836 |
Target Information
IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine belonging to the IFN-IL-10 family (IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons). It is mainly produced by activated T cells and NK cells.
In humans, the IL-22 gene resides on chromosome 12q and is structurally related to IL-10. IL-22 interacts with a heterodimeric receptor complex composed of IL-22R1 and IL-10R2, initiating JAK-STAT signaling. A soluble receptor variant, IL-22BP, antagonizes IL-22 binding and signaling.
IL-22 primarily targets nonimmune cells such as keratinocytes, hepatocytes, and epithelial cells of the skin, digestive, and respiratory systems. It functions as an effector cytokine of Th17 cells, co-expressed with IL-17A and IL-17F but regulated differently.
IL-22 induces acute phase reactants, antimicrobial proteins, and promotes keratinocyte mobility. It is upregulated during chronic inflammation, activating intracellular kinases and transcription factors, and plays critical roles in defense against extracellular pathogens and wound healing.
IL-22 mediates IL-23-induced acanthosis and dermal inflammation via STAT3 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.