Thermo Fisher Scientific IL-22 Monoclonal Antibody (2A10B9)

Thermo Fisher Scientific IL-22 Monoclonal Antibody (2A10B9)

Applications and Tested Dilutions

Product Specifications

Target Information

IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine belonging to the IFN-IL-10 family (IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons). It is mainly produced by activated T cells and NK cells.
In humans, the IL-22 gene resides on chromosome 12q and is structurally related to IL-10. IL-22 interacts with a heterodimeric receptor complex composed of IL-22R1 and IL-10R2, initiating JAK-STAT signaling. A soluble receptor variant, IL-22BP, antagonizes IL-22 binding and signaling.
IL-22 primarily targets nonimmune cells such as keratinocytes, hepatocytes, and epithelial cells of the skin, digestive, and respiratory systems. It functions as an effector cytokine of Th17 cells, co-expressed with IL-17A and IL-17F but regulated differently.
IL-22 induces acute phase reactants, antimicrobial proteins, and promotes keratinocyte mobility. It is upregulated during chronic inflammation, activating intracellular kinases and transcription factors, and plays critical roles in defense against extracellular pathogens and wound healing.
IL-22 mediates IL-23-induced acanthosis and dermal inflammation via STAT3 activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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