Thermo Fisher Scientific Desmoglein 3 Monoclonal Antibody (5G11)
Desmoglein 3 단백질을 인식하는 Mouse Monoclonal 항체로, Western blot, IHC, ICC 등 다양한 응용에 사용 가능. Human에 반응하며 Protein A로 정제된 액상 형태. 세포 간 접착 관련 연구 및 pemphigus vulgaris 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 11 publications |
| Immunohistochemistry (IHC) | 20–50 µg/mL | View 8 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | – | View 4 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | – | View 12 publications |
| Flow Cytometry (Flow) | – | View 1 publication |
| Immunoprecipitation (IP) | 5–10 µg | View 1 publication |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
| SDS-PAGE | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Bovine, Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5G11 |
| Immunogen | Human desmoglein-3 extracellular domain |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533091 |
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion.
It is predominantly expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus.
Desmoglein 3 has been characterized as the autoantigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease.
Binding of anti-Desmoglein 3 autoantibodies causes loss of cell-cell adhesion, clinically resulting in blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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