Thermo Fisher Scientific Desmoglein 3 Monoclonal Antibody (5G11)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-3 µg/mL

View 11 publications 11 publications

Immunohistochemistry (IHC)

20-50 µg/mL

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

-

View 4 publications 4 publications

Immunohistochemistry (Frozen) (IHC (F))

-

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

-

View 12 publications 12 publications

Flow Cytometry (Flow)

-

View 1 publication 1 publication

Immunoprecipitation (IP)

5-10 µg

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

-

View 2 publications 2 publications

SDS-PAGE (SDS-PAGE)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Bovine, Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

5G11

Immunogen

Human desmoglein-3 extracellular domain.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533091

Target Information

Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.