Thermo Fisher Scientific GPX3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide is homologous in many species including rat and mouse.
• Specificity: GPX3.

Target Information

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins that catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione.
There are several isoforms differing in structure and localization:

• GPx1 (cGPx): Cytosolic/mitochondrial, selenium-dependent enzyme, first discovered in the GPx family.
• GPx2 (GI-GPx): Expressed in the gastrointestinal epithelium.
• GPx3 (pGPx): Extracellular plasma GPx, mainly expressed by the kidney and secreted into blood circulation.
• GPx4 (PH-GPx): Reduces various hydroperoxides including membrane-integrated forms and lipoprotein-associated hydroperoxy lipids.

All mammalian GPx family members, except for the recently described Cys-containing GPx3 and epididymis-specific GPx5 isoforms, possess selenocysteine at the active site.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.