Thermo Fisher Scientific Coilin Polyclonal Antibody
Rabbit polyclonal antibody targeting human Coilin protein. Validated for Western blot and IHC (paraffin). Detects endogenous Coilin in human, mouse, and rat samples. Supplied as liquid, 1 mg/mL, affinity purified, stored at -20°C. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human COIL (Accession P38432), corresponding to amino acid residues G371–H421 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815568 |
Product Specific Information
Antibody detects endogenous levels of total Coilin.
Target Information
The Coilin protein is an integral component of Cajal bodies (also called coiled bodies), which are nuclear suborganelles involved in post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of coilin directs self-oligomerization, while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely affect its localization among nuclear bodies and the composition of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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